Bioactivity-guided isolation of cytotoxic constituents of Brucea javanica collected in Vietnam
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چکیده
منابع مشابه
Bioactivity-guided isolation of cytotoxic constituents from three medicinal plants.
CONTEXT The ethanol extracts and their fractions of three Indian medicinal plants, Ervatamia coronaria (Jacq.) Stapf, (Apocynaceae), Mimosa pudica L. (Mimosaceae) and Caesalpinia bonduc (L.) Roxb. (Caesalpiniaceae) were tested for their cytotoxic activity in the brine shrimp lethality (BSL) bioassay and in various cancer cell lines. The plants were selected based on their traditional use in the...
متن کاملChemical Composition and Cytotoxic Activities of Petroleum Ether Fruit Extract of Fruits of Brucea javanica (Simarubaceae)
Purpose: To investigate the chemical composition and antitumor activity of the petroleum ether extract of the dried ripe fruits of Brucea javanica. Methods: The composition of petroleum ether extract was analyzed by gas chromatography/mass spectrometric (GC/MS) and their antitumor activities were determined by MTT assay. Results: GC/MS spectrometry results indicate that the petroleum ether extr...
متن کاملIsolation of antibabesial compounds from Brucea javanica, Curcuma xanthorrhiza, and Excoecaria cochinchinensis.
One new curcuminoid, 3'-demethoxycyclocurcumin (1), was isolated from Curcuma xanthorrhiza as an antibabesial compound, together with p-hydroxybenzaldehyde (2) and cleomiscosin A (3) from Brucea javanica and (+)-epiloliolide (4) from Excoecaria cochinchinensis. The antibabesial activities were examined in vitro, and compounds 1-4, and diminazene aceturate were studied with IC(50) values of 16.6...
متن کاملBioactivity-guided isolation of antioxidant and anti-hepatocarcinoma constituents from Veronica ciliata
BACKGROUND Veronica ciliata Fisch., widely distributed in western China, has been traditionally used in Tibetan Medicine as a treatment for hepatitis, cholecystitis, rheumatism, and urticaria. However, V. ciliata Fisch. has not been subjected to detailed chemical constitution analysis and the bioactive studies were restricted to its crude extracts. It is necessary to investigate the active chem...
متن کاملBioactivity-guided isolation of cytotoxic triterpenoids from the trunk of Berberis koreana.
A bioassay-guided fractionation and chemical investigation of the trunk of Berberis koreana resulted in the isolation and characterization of two new triterpenoids, 23-trans-p-coumaroyloxy-2alpha,3alpha-dihydroxyolean-12-en-28-oic acid (1), and 23-cis-p-coumaroyloxy-2alpha,3alpha-dihydroxyolean-12-en-28-oic acid (2), along with seven known triterpenoids (3-9). The structures of the new compound...
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry
سال: 2009
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2008.10.076